- Pack of 36, double strength, mood-balancing, 400 milligram SAM-e tablets
- Clinically proven to help with mood support, joint comfort and liver health
- Replenishes chemicals that affect mood; contains 400 mg of SAM-e per serving tablet
- Relieves joint pain; repairs joint cartilage
Product Description
Dietary Supplement. S-Adenosylmethionine. Clinically Proven: Mood Support; Joint Comfort; Liver Health. Sam-E (S-Adenosylmethionine) is a naturally occurring compound found in all living organisms. In humans, Sam-E is distributed throughout the body and is involved in may biochemical processes. Since significant amount of Sam-E are not available through diet alone, the body is primarily responsible for producing its own Sam-e. Scientists know that Sam-e declines as people age and that certain groups of people, including those with low mood and liver conditions, tend to have lower levels of Sam-E in their bodies. Over 100 clinical studies involving thousands of people have proven that Sam-E supplementation benefits a multitude of body functions including: Mood Support – Enhances mood by promoting a healthy balance of neurotransmitters, dopamine and serotonin, which are part of overall healthy brain cell functions. Joint Comfort – Promotes joint health by helping to maintain joint cartridge which naturally deteriorates with physical activity and age. Liver Health – Helps support detoxification and overall healthy liver functions. MoodPlus Sam-E is the same form of Sam-E available and administered for over 20 years by doctors in Europe. It is the only form of Sam-E studied in over two decades of research, as well as the most documented form in respected medical journals. Short and long-term studies have proven that Sam-E is a safe, non-toxic and efficacious product to support your health. Sam-E Tablets made to Nature Made’s guaranteed purity and potency standards. Made in Italy. (These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.)
Nature Made SAM-e Complete, 400mg Tablets, 36 Tablets







Sam-E has worked well for me, after I knew how to take it properly that is. I took it for about 2 weeks before I actually did some reading about it and knew I was doing many things wrong. Including making the wrong purchase. Any brand will probably do, (as long as it is made properly, see #2 below) but I have found Nature Made to be the best selection when it came to purchasing Sam-E. (Yes, I have actually bought and tried the 200mg AND 400mg tablets) No matter what brand you buy, you have to give it TIME to work. 7-10 days is the timeframe that it will typically start to work in, but I have heard of occasions where it has taken longer. After 12 days if you have seen no positive change in mood, up the dose. Eventually, work your way up to taking 1200mg of Sam-E daily for best results.
Yes, these 400mg tablets ARE enteric coated, which you definitely want in your Sam-E supplement…more on this later.
Stomach Cramps and even the possibility of ulcers be a serious problem for people taking Sam-E. I have compiled a list of precautions and things you can do to prevent this:
1) Make sure you take this product on an EMPTY STOMACH. An empty stomach means not having eaten anything for roughly an hour. The best time to take this is in the morning, right after waking up. Finally, make sure you do not eat for at least 30 MINUTES after taking Sam-e. More time may be required as you take more of the supplement.
2) Do NOT purchase Sam-E tablets that are not enteric coated and are not in a box/blister wrap. The Entric coating prevents the pills from being absorbed by your body until they reach the lower intestine which will prevent a majority of stomach cramps and stomach pains. Not only this, but it will prevent the Sam-E from being dissolved in the stomach which renders it virtually useless. Again, the Nature Made 400mg tablets ARE enteric coated.
Also, On a lot of the “Product Ads from External Websites,” I have seen a lot of retailers trying to hawk Sam-E in bottles…NOT ok! It is a BIG mistake to buy Sam-E in bottles, I won’t get onto it here but you can google it and you will see why. It must be blister wrapped for ultimate freshness!
I hope I have been of assistance, if taken right you will see a dramatic positive change in your mood!
Rating: 5 / 5
I was diagnosed with Fibromyalgia Syndrome in late 2001 (I have a very severe debilitating case). I began taking SAMe in May of 2002 with a small dosage of 100mg (another brand). I immediately was 35% better, so began Nature Made SAMe at 200mg a day. I now take 400Mg a day, and after taking it for years now, I function 75% better versus without it. I have planned to increase to 800Mg to try for a 100% (we can hope can’t we?
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SAMe allows me to get out of bed, to move more fluidly, to feel good about facing the day, and CONTROLS MY PAIN in a way nothing else can. I cannot function without it.
I STRONGLY suggest this product for anyone suffering from a muscular, arthritic, or brain related disease that causes pain or discomfort. However you should see your doctor or a specialist before starting any new medication.
Rating: 5 / 5
I read about Sam-e in a book called Stop Depression Now, written by an M.D. and a PHd. I bought this product at a local Rite-Aid for a friend of mine who was so depressed that he couldn’t work or function, and was borderline suicidal. Within a couple days, he said he didn’t feel suicidal anymore. Within a week, he was back to taking care of himself, laughing and joking, has renewed interest in things he liked to do, and is now back to work!! He is like a different person! He started telling all his friends about it that are taking Prozac with no results. I’m amazed at the major changes and so quickly. He doubled up on this so is taking 800mg a day. According to the book, you would start out at 400mg per day, if no results within a week, then up it to 800mg. Like the books says, you also need a good B vitamin complex in addition to this. I gave him a really effective sublingual B tablet that makes a big difference for me also.
Rating: 5 / 5
SAM-E has been prescribed for many years in Europe for mild clinical depression and osteoarthritis, and there is quite a lot of good clinical data that it does indeed work, and without serious side effects. There’s also one small study that suggests it may help with adult ADHD, and I believe it has helped with my symptoms.
Rating: 5 / 5
I started taking Sam-e over a month ago and I love it! Before starting it I was experiencing anxiety and panic attacks coupled with mood swings. I started keeping track of my mood and realized that I was having more bad days than good. Even little things would upset me and it was like once something happened (no matter how small) it just ruined my mood sometimes for a few hours and sometimes for the rest of the day. I ordered my Sam-e from wholehealth.com because they include a free bottle of Vitamin B Complex with each order. Sam-e can cause a build up of homocysteine in your system which is correlated with heart disease. The B Complex prevents homocysteine build up. I’m currently taking 400 mg a day. It started working quickly and I’ve experienced no side effects. I’ve been taking it for over a month and I just have a general sense of well being. I feel happier and I’m not having panic attacks anymore. I’ve taken Paxil in the past and this is less expensive and without the side effects. [...]. Read up on the benefits of taking a B Complex with it. It’s worth mentioning that B Complex contains Vitamin B2 also called Riboflavin. When you take a Vitamin B supplement your body uses what it needs and if it’s more than it needs the remainder of the B vitamin is excreted in your urine causing the urine to be very bright yellow. I strongly recommend Sam-e. It really has changed my life. Yes, seriously.
Rating: 5 / 5